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Sherbrooke is a city in the province of Quebec, Canada. Sherbrooke is located in the Estrie administrative area, near the confluence of the Saint-François (St. Francis) and Magog rivers. Sherbrooke is also the name of a territory in Quebec, coextensive with the city of Sherbrooke, that is comparable to a regional county municipality (TE) and census division (CD). It is the sixth biggest city in the province and the thirty-first largest in Canada, with 161,323 people according to the 2016 census. The Sherbrooke Census Metropolitan Area has 212,105 people, making it the fourth biggest in Quebec and the nineteenth largest in Canada.

It was formerly known as Hyatt's Mill until being renamed after Sir John Coape Sherbrooke (1764–1840), a British officer who served as Lieutenant Governor of Nova Scotia (1812–1816) and Governor General of British North America (1816–1818); the family is called after Shirebrook, Derbyshire.

Sherbrooke is Estrie's major economic, political, cultural, and institutional center, and was regarded as the Queen of the Eastern Townships at the turn of the twentieth century.

There are eight schools that educate 40,000 students and employ 11,000 people, including 3,700 professors, instructors, and researchers. These institutions have a direct economic effect that surpasses one billion dollars. The percentage of university students per 100 people is 10.32. Sherbrooke has the highest concentration of students in Quebec in relation to its population.

Sherbrooke has been a manufacturing center since the nineteenth century. As a result of the loss of the city's historic industrial industries, this sector of the economy has undergone significant upheaval in recent decades. Along with a developing knowledge-based economy, the service sector plays an important role in the city's economy.

Mountains, rivers, and lakes surround the Sherbrooke area. There are many ski hills nearby, as well as a variety of tourist sites with a regional flavor. Downhill skiing is popular in Mont-Bellevue Park, a major park in the city.