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Denver, formally the City and County of Denver, is the capital and most populous city of Colorado, located in the United States. It is situated in the South Platte River Valley on the western border of the High Plains, just east of the Rocky Mountains' Front Range. Denver is the 19th-most populated city in the United States, the fifth-most populous state capital, and the most populous city in the Mountain states, with an anticipated population of 735,538 in 2020. The Denver metropolitan area contains the majority of the population and economic activity of the Front Range region, which is home to an estimated 85 percent of Colorado's population.

The Denver downtown district is located just east of the confluence of Cherry Creek and the South Platte River, roughly 12 miles (19 kilometers) east of the Rocky Mountain foothills. The city of Denver is named after James W. Denver, the governor of the Kansas Territory. The Mile High City is so named because its official elevation is precisely one mile (5280 feet or 1609.344 meters) above sea level. The longitudinal reference for the Mountain Time Zone, the 105th meridian west of Greenwich, runs right through Denver Union Station.

The Globalization and World Cities Research Network has designated Denver as a Beta world city. The 10-county Denver-Aurora-Lakewood, CO Metropolitan Statistical Region has an estimated population of 2,932,415 in 2018, making it the 19th most populated metropolitan statistical area in the United States. The 12-county Denver-Aurora, CO Combined Statistical Region had a population of 3,572,798 in 2018 and was the 15th most populated metropolitan area in the United States. With an estimated 2018 population of 4,976,781, Denver was the most populous city of the 18-county Front Range Metropolitan Corridor, an oblong urban area spanning two states. The Denver metropolitan region is the most populated within an 800-mile (1,290 km) radius and the Mountain West's second-most populous city after Phoenix, Arizona. U.S. News & World Report ranked Denver the greatest location to live in the United States in 2016.